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Ann Acad Med Stetin

15 The biologic consequences of the activation and degranulation of mast cells in the rheumatoid synovial tissue are complex and despite their ability to mediate inflammation was neglected for years, the mast cell and its products are now recognized as novel targets for therapy of rheumatoid arthritis

Hence the evidence is not adequate to make clinical recommendations

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[22] Others [edit] Azathioprine is sometimes used in systemic lupus erythematosus, requiring a maintenance dose of 15 mg or higher of prednisone in those who experience recurrent flares

Cardiovascular safety profile of currently available diabetic drugs